إليك الترجمة الأكاديمية والاحترافية لهذا الإنجاز العلمي:
Faculty Member at the College of Pharmacy, Al-Zahraa University (PBUH) for Women, Publishes Research on Nano-Drug Delivery Systems for Breast Cancer Treatment
Asst. Prof. Dr. Dhiaa Rahim Al-Tamimi, a faculty member at the College of Pharmacy, Al-Zahraa University (PBUH) for Women, has achieved a significant scientific milestone by publishing his research titled: “SILK FIBROIN-COATED MESOPOROUS SILICA NANOPARTICLES ENHANCE 6-THIOGUANINE DELIVERY AND CYTOTOXICITY IN BREAST CANCER CELLS” in the International Journal of Applied Pharmaceutics, an international journal indexed in Scopus and ranked within the Second Quartile (Q2).
The study aims to develop an advanced nano-system to improve the delivery efficiency of 6-Thioguanine, a chemotherapy drug used for breast cancer. Breast cancer is one of the most common cancers among women worldwide, and traditional treatments often face challenges such as poor drug solubility and low targeting efficiency to cancer cells.
To address these issues, the researcher designed a nano-system utilizing Mesoporous Silica Nanoparticles (MSNs) loaded with the drug and coated with Silk Fibroin protein. This design aims to enhance pharmacokinetic properties and increase targeting precision for breast cancer cells.
The study included an evaluation of the cytotoxicity of various formulations using the MTT assay, as well as an analysis of cell death (apoptosis).
